Hyperbaric Center Some treatments could be as simple as a medication change, but in other, more complex situations, debridements, skin substitutes or hyperbaric oxygen therapy may be needed. The care team will work with you to develop a plan individualized to your needs and help you through the healing process. Indications for hyperbaric oxygen therapy: Diabetic foot ulcers Chronic refractory osteomyelitis Soft tissue radionecrosis Osteoradionecrosis Compromised skin grafts/failed flaps Acute peripheral arterial insufficiency Acute traumatic peripheral ischemia Necrotizing soft tissue infections Crush injuries, compartment syndrome Complications of reattached extremity or body part Actinomycosis (refractory) Gas gangrene Air or gas embolism Carbon monoxide poisoning Cyanide poisoning Decompression sickness